Drug-induced notched T waves

The significance of notched upright T waves.

Cardiological texts yield scant information on the significance of notching of upright T waves. White (1948) states briefly: " The T wave is frequently diphasic but rarely notched ... A late notch or dip in a low T wave in lead II suggests the effect of heart position in an otherwise normal person." Katz (1947) points out that notching of the T wave is abnormal in the limb leads but may be obse...

Notched T waves on Holter recordings enhance detection of patients with LQt2 (HERG) mutations.

BACKGROUND The 2 genes KCNQ1 (LQT1) and HERG (LQT2), encoding cardiac potassium channels, are the most common cause of the dominant long-QT syndrome (LQTS). In addition to QT-interval prolongation, notched T waves have been proposed as a phenotypic marker of LQTS patients. METHODS AND RESULTS The T-wave morphology of carriers of mutations in KCNQ1 (n=133) or HERG (n=57) and of 100 control sub...

Notched T waves in young persons with central nervous system lesions.

A STRIKING, characteristic, electrocardiographic pattern associated with central nervous system (CNS) lesions, particularly subarachnoid hemorrhage, has been described.1-3 The combination of prolonged Q-T interval and large upright or deeply inverted T waves was originally described in association with cerebrovascular accidents and has come to be recognized as the typical CNS electrocardiogram....

Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.

The heart rhythm disorder long QT syndrome (LQTS) can result in sudden death in the young or remain asymptomatic into adulthood. The features of the surface electrocardiogram (ECG), a measure of the electrical activity of the heart, can be equally variable in LQTS patients, posing well-described diagnostic dilemmas. Here we report a correlation between QT interval prolongation and T-wave notchi...

Drug-induced T wave alternans.